Related Experiment Video

Updated: Oct 3, 2025

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
11:07

Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging

Published on: November 24, 2021

2.9K

A practical guide to the safety of topical medications for the pediatric population

Manal Fawzy1, Basma ElKholy1

  • 1Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.

Dermatologic Therapy
|February 14, 2022
PubMed

Insights

Pediatric topical therapy requires careful consideration due to increased risks of side effects in children. This guide offers essential information on medication safety, precautions, and age restrictions for pediatric topical treatments.

Area of Science:

  • Pediatric Dermatology
  • Clinical Pharmacology
  • Drug Safety

Background:

  • Children exhibit heightened susceptibility to adverse effects from topical medications compared to adults.
  • Topical drug administration in pediatric patients necessitates distinct safety considerations.

Purpose of the Study:

  • To equip clinicians with a practical guide for prescribing topical therapies to pediatric patients.
  • To detail potential local and systemic side effects of common topical medications in children.
  • To provide guidance on precautions and minimum age limits for pediatric topical drug use.

Main Methods:

  • Review of existing literature on pediatric topical drug pharmacology and toxicology.
  • Compilation of data on side effect profiles for commonly used pediatric topical agents.
  • Development of evidence-based recommendations for safe pediatric topical prescribing.

Main Results:

  • Identification of specific local and systemic side effects associated with various topical medications in children.
  • Establishment of age-related safety considerations and contraindications for topical drug use.
  • Outline of practical precautions to mitigate risks during pediatric topical therapy.

Conclusions:

  • Safe and effective topical therapy in children demands a thorough understanding of drug-specific risks.
  • Adherence to recommended precautions and age guidelines is crucial for minimizing adverse events.
  • This guide serves as a valuable resource for optimizing topical medication use in the pediatric population.

Keywords:
childrenpediatric populationsafetyside effectstopical therapy

More Related Videos

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis11:39

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis

Published on: July 11, 2013

39.1K
A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings06:59

A Novel Approach for the Administration of Medications and Fluids in Emergency Scenarios and Settings

Published on: November 9, 2016

30.7K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
9
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
8
Drug Dosing: Infants and Children01:29

Drug Dosing: Infants and Children

Pediatric patient dosages diverge from adults due to disparities in body surface area, total body water, and extracellular fluid per kilogram of body weight. The dosing regimen considers the variations in pharmacokinetics and pharmacology across distinct age groups, encompassing preterm newborns, infants, young children, older children, and adolescents. Calculation of pediatric patient doses is predicated on determining body surface area, which exhibits a superior correlation with the child's...
19
Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption01:23

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...
11
Pharmacokinetics in Pediatric Patients: Drug Metabolism01:24

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...
16
Factors Affecting Drug Response: Overview01:21

Factors Affecting Drug Response: Overview

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
2.5K