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Updated: Oct 3, 2025

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
Published on: December 19, 2016
Nobel somatosensations and pain
Peter W Reeh1, Michael J M Fischer2
1Institute of Physiology and Pathophysiology, University of Erlangen-Nürnberg, Universitätsstrasse 17, 91052, Erlangen, Germany. peter.reeh@fau.de.
Abstract:
The Nobel prices 2021 for Physiology and Medicine have been awarded to David Julius and Ardem Patapoutian "for their discoveries of receptors for temperature and touch", TRPV1 and PIEZO1/2. The present review tells the past history of the capsaicin receptor, covers further selected TRP channels, TRPA1 in particular, and deals with mechanosensitivity in general and mechanical hyperalgesia in particular. Other achievements of the laureates and translational aspects of their work are shortly treated.
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