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Updated: Oct 3, 2025

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An Efficient and Simple Method to Establish NK and T Cell Lines from Patients with Chronic Active Epstein-Barr Virus Infection
Published on: March 30, 2018
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Chronic active Epstein-Barr virus infection presenting as refractory chronic sinusitis
Wataru Kitamura1, Hideaki Fujiwara2, Akifumi Matsumura1
1Department of Hematology and Oncology, Okayama University Hospital, 2-5-1, Shikata-cho, Kita-ku, Okayama, 700-8558, Japan.
International Journal of Hematology
|February 14, 2022
Summary
Chronic active Epstein-Barr virus (CAEBV) infection can cause persistent sinusitis, leading to extranodal natural killer/T-cell lymphoma (ENKTL) and hemophagocytic lymphohistiocytosis (HLH) in adults. Consider CAEBV in refractory sinusitis cases.
Area of Science:
- Infectious Diseases
- Oncology
- Immunology
Background:
- Refractory chronic sinusitis can be a challenging clinical presentation.
- Extranodal natural killer/T-cell lymphoma, nasal type (ENKTL) is an aggressive malignancy.
- Hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome.
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