[Immunoenzyme method in the diagnosis of tick-borne encephalitis]

Data are presented on the use of direct and indirect enzyme-immunoassay (EIA) in the study of tick-borne encephalitis (TBE) virus. EIA has been shown to be considerably more effective than the conventional CFT and HI tests exceeding them in sensitivity by 50-150 times both in studies of the antigenic activity of various preparations and in examinations of human sera. The possibility of testing various antigenic substrates makes EIA a universal method suitable for numerous studies. The high sensitivity of the method is useful for antigenic differentiation of viruses and strains within the TBE complex. The EIA may be used satisfactorily for early diagnosis of TBE and study of seroconversion in vaccines.