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Related Concept Videos

Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

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Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
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IntroductionThe management of Acute Coronary Syndrome (ACS) aims to minimize myocardial damage, preserve myocardial function, and prevent complications.Initial ManagementInpatient management involves continuous cardiac monitoring, preferably in an ICU, focusing on blood pressure, serum sodium, potassium, and creatinine levels, and urine output. Ongoing pharmacologic management is crucial for stabilizing the patient.Supplemental Oxygen: Administer supplemental oxygen if oxygen saturation is...
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Related Experiment Video

Updated: Oct 3, 2025

A Hydrogel Construct and Fibrin-based Glue Approach to Deliver Therapeutics in a Murine Myocardial Infarction Model.
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Nanoengineered Sprayable Therapy for Treating Myocardial Infarction.

Marcelo Muñoz1, Cagla Eren Cimenci1,2, Keshav Goel1

  • 1BEaTS Research, Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario K1Y 4W7, Canada.

ACS Nano
|February 14, 2022
PubMed
Summary

A novel sprayable nanotherapeutic using peptide-grafted nanogold effectively coats infarcted heart surfaces. This treatment significantly improves cardiac function and promotes tissue regeneration without off-target effects.

Keywords:
cardiovascular diseasesheart musclemyocardial infarctionnanogoldpeptides

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cardiovascular Research

Background:

  • Myocardial infarction (heart attack) leads to significant cardiac damage and functional decline.
  • Current regenerative therapies for infarcted hearts have limitations in application and efficacy.

Purpose of the Study:

  • To develop and evaluate a novel sprayable nanotherapeutic for treating myocardial infarction.
  • To assess the *in vitro* and *in vivo* efficacy and safety of peptide-grafted nanogold for cardiac repair.

Main Methods:

  • Development of a sprayable nanotherapeutic using surface-engineered, multiarmed peptide-grafted nanogold.
  • Application of the nanotherapeutic to infarcted mouse hearts *in vivo*.
  • Assessment of cardiac function, electrical conductivity, infarct size, vascularization, and immune cell infiltration post-treatment.

Main Results:

  • Spray-on nanogold treatment significantly increased cardiac function (2.4-fold), contractility, and electrical conductivity.
  • The nanogold remained localized to the treatment site for 28 days with no observed off-target organ infiltration.
  • Treated hearts showed reduced infarct size (<10% of left ventricle area) and increased blood vessels, prohealing macrophages, and cardiomyocytes.

Conclusions:

  • The sprayable nanotherapeutic demonstrates high therapeutic efficacy for treating infarcted myocardial surfaces.
  • This approach offers a simpler and potentially more effective alternative to existing regenerative strategies for cardiac repair.