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A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
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¿ Can COVID-19 exacerbate multiple sclerosis symptoms? A case series analysis
Gloria Michelena1, Magdalena Casas2, María Bárbara Eizaguirre2
1Hospital Militar Central Dr. Cosme Argerich, CABA, Argentina.
Multiple Sclerosis and Related Disorders
|February 15, 2022
Summary
COVID-19 infection may worsen symptoms in Multiple Sclerosis (MS) patients, potentially triggering exacerbations. Further research is needed to understand this link between SARS-CoV-2 and MS progression.
Area of Science:
- Neuroimmunology
- Infectious Diseases
Background:
- Peripheral inflammation is known to worsen Central Nervous System (CNS) lesions in neurodegenerative diseases like Multiple Sclerosis (MS).
- COVID-19 infection causes peripheral inflammation, necessitating an investigation into its effects on MS patients.
Purpose of the Study:
- To analyze the clinical impact of COVID-19 infection on patients diagnosed with Multiple Sclerosis (MS).
Main Methods:
- Retrospective analysis of 400 MS patient medical records.
- Surveyed 41 MS patients with COVID-19 regarding symptom exacerbation, vaccination status, and disease severity.
- Utilized GraphPad Prism V6 for descriptive and inferential statistical analysis.
Main Results:
- 61% of MS patients reported neurological worsening following COVID-19 infection.
- A significant difference in Expanded Disability Status Scale (EDSS) was observed between patients with and without symptom exacerbation (p=0.03).
- EDSS was independently associated with MS exacerbations during SARS-CoV-2 infection (OR=2.44, p=0.022).
Conclusions:
- Preliminary findings suggest COVID-19 may trigger exacerbations in MS patients.
- Further studies are required to clarify the relationship between COVID-19 and MS.
- This research highlights a potential clinical concern for MS patients contracting SARS-CoV-2.
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