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Urinary C5b-9 as a Prognostic Marker in IgA Nephropathy

Byung Chul Yu1, Jin Hoon Park1, Kyung Ho Lee1

  • 1Division of Nephrology, Department of Internal Medicine, Soonchunhyang University Bucheon Hospital, 170 Jomaru-ro, Bucheon 14584, Korea.

Journal of Clinical Medicine
|February 15, 2022
PubMed

Insights

Urinary C5b-9 levels correlate with proteinuria and kidney function changes in IgA nephropathy (IgAN) patients. However, urinary C5b-9 is not yet a reliable prognostic biomarker for IgAN outcomes.

Area of Science:

  • Nephrology
  • Immunology
  • Biomarker Research

Background:

  • Immunoglobulin A nephropathy (IgAN) pathogenesis involves the complement system, specifically the terminal complement complex C5b-9.
  • Evaluating novel biomarkers is crucial for predicting IgAN progression and treatment response.

Purpose of the Study:

  • To assess the prognostic value of urinary C5b-9 levels in patients with IgAN.
  • To investigate the correlation between urinary C5b-9 and clinical outcomes, including proteinuria and estimated glomerular filtration rate (eGFR).

Main Methods:

  • Prospective enrollment of 33 patients with biopsy-proven IgAN.
  • Analysis of baseline and post-treatment urinary C5b-9 levels.
  • Correlation analysis with proteinuria, eGFR changes, and treatment response.

Main Results:

  • Baseline urinary C5b-9 positively correlated with proteinuria at diagnosis (r = 0.548, p = 0.001).
  • Post-treatment changes in urinary C5b-9 correlated with proteinuria and inversely with eGFR changes at 6 months.
  • Urinary C5b-9 changes correlated with time-averaged proteinuria but not eGFR decline rate.
  • Baseline urinary C5b-9 was not an independent predictor of treatment response (OR 0.997, p = 0.078).

Conclusions:

  • Urinary C5b-9 shows correlations with proteinuria and kidney function parameters in IgAN.
  • Current evidence suggests urinary C5b-9 is not a sufficiently promising prognostic biomarker for IgAN.
  • Further research is warranted to explore the role of urinary C5b-9 in IgAN.

Keywords:
IgA nephropathycomplement system proteinsmembrane attack complexprognostic markerurinary C5b-9

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