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[Enzymatic synthesis of peptides]
Antibiotiki I Meditsinskaia Biotekhnologiia = Antibiotics and Medical Biotechnology
|February 1, 1986
Summary
Enzymatic synthesis offers a greener alternative for creating biologically active peptides like enkefalin and endorphin. This review compares enzymatic methods to chemical synthesis, highlighting pros and cons.
Area of Science:
- Biochemistry
- Organic Chemistry
- Enzymology
Context:
- Biologically active peptides are crucial in medicine and research.
- Chemical synthesis of peptides can be complex and environmentally taxing.
- Proteolytic enzymes offer alternative catalytic routes.
Purpose:
- To review the status of enzymatic peptide synthesis using proteolytic enzymes.
- To outline key peptide synthesis processes (enkefalin, angiotensin, cholecystokinin, endorphin) reported before 1985.
- To compare the advantages and disadvantages of enzymatic versus chemical peptide synthesis.
Summary:
- Discusses the use of proteolytic enzymes (trypsin, chymotrypsin, papain) as catalysts for synthesizing biologically active peptides.
- Details specific examples of peptide synthesis, including enkefalin, angiotensin, cholecystokinin, and endorphin, as described in literature up to 1985.
- Presents a comparative analysis of enzymatic and chemical synthesis methods, evaluating their respective benefits and drawbacks.
Impact:
- Provides a historical overview of enzymatic peptide synthesis techniques.
- Highlights the potential of enzymatic methods as a more sustainable approach to peptide production.
- Informs future research and development in peptide synthesis by outlining established methodologies and their comparative efficiencies.