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Obesity and Thyroid Cancer Risk: An Update
Fabiana Franchini1, Giuseppe Palatucci1, Annamaria Colao1
1Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Napoli, Italy.
International Journal of Environmental Research and Public Health
|February 15, 2022
Summary
Obesity may increase thyroid cancer (TC) risk. Mechanisms like chronic inflammation and insulin resistance link excess weight to TC development and growth. This review explores the latest evidence.
Area of Science:
- Endocrinology
- Oncology
- Public Health
Background:
- Thyroid cancer (TC) is the most common endocrine malignancy globally.
- Recent years have seen a dramatic increase in TC incidence.
- Obesity prevalence has also risen concurrently, suggesting a potential link.
Purpose of the Study:
- To review the most recent evidence linking obesity to thyroid cancer.
- To discuss the underlying biological mechanisms involved.
Main Methods:
- Literature review of recent scientific evidence.
- Analysis of studies investigating obesity and thyroid cancer.
Main Results:
- Obesity is associated with factors promoting TC, including chronic inflammation, altered cytokines, insulin resistance, oxidative stress, and hormonal changes.
- These factors are implicated in both the occurrence and progression of thyroid cancer.
Conclusions:
- Obesity presents a significant risk factor for thyroid cancer.
- Understanding the mechanistic links between obesity and TC is crucial for prevention and treatment strategies.
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