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Recent Progress in Biopolymer-Based Hydrogel Materials for Biomedical Applications.

Ayaz Mahmood1, Dev Patel2, Brandon Hickson2

  • 1Department of Physics and Astronomy, Rowan University, Glassboro, NJ 08028, USA.

International Journal of Molecular Sciences
|February 15, 2022
PubMed
Summary

Biopolymer-based hydrogels offer versatile solutions in biomedicine, enabling advanced applications in tissue regeneration and controlled drug delivery. Recent developments since 2015 highlight their potential for improved patient treatments and outcomes.

Keywords:
biopolymerdrug deliveryhydrogelpolypeptidepolysaccharideproteintissue engineering

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Biomedical Engineering

Background:

  • Hydrogels synthesized from biopolymers like polysaccharides and polypeptides are extensively utilized in biomedicine.
  • These hydrogels offer tunable characteristics suitable for diverse therapeutic applications.
  • Examples include collagen, gelatin, alginate, and cellulose-based hydrogels.

Purpose of the Study:

  • To review newly developed biopolymer-based hydrogel materials primarily created since 2015.
  • To summarize their demonstrated efficacy and potential for advanced medical applications.
  • To highlight their use in tissue regeneration and drug delivery systems.

Main Methods:

  • Review of recent literature on biopolymer-based hydrogels (post-2015).
  • Analysis of hydrogel synthesis, characterization theories (e.g., Flory-Rehner, Rubber Elasticity Theory), and fabrication processes.
  • Categorization of hydrogels based on sensitivity (pH, temperature, electric field, light) and application.

Main Results:

  • Biopolymer hydrogels are readily synthesized with tunable properties for specific biomedical uses.
  • Various biopolymers (polysaccharides, polypeptides) form hydrogels with distinct characteristics.
  • These advanced hydrogels are effective in cell delivery for tissue regeneration and controlled release of drugs and biomolecules.

Conclusions:

  • Biopolymer-based hydrogels represent a significant advancement in medical treatments.
  • Their versatility supports applications ranging from structural repair to sophisticated drug delivery systems.
  • Continued research and development promise further innovations in patient care and therapeutic outcomes.