Related Experiment Video

Updated: Oct 3, 2025

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues
08:56

A Method for Measuring RNA N6-methyladenosine Modifications in Cells and Tissues

Published on: December 5, 2016

11.1K

m6A modification: recent advances, anticancer targeted drug discovery and beyond

Li-Juan Deng1, Wei-Qing Deng1,2, Shu-Ran Fan2

  • 1Formula-pattern Research Center, School of Traditional Chinese Medicine, Jinan University, Guangzhou, China.

Molecular Cancer
|February 15, 2022
PubMed

Insights

Abnormal N6-methyladenosine (m6A) modification is linked to cancer. This review explores traditional medicines and AI for discovering new m6A-targeting anticancer drugs.

Area of Science:

  • Oncology
  • Epigenetics
  • Pharmacology

Background:

  • Aberrant N6-methyladenosine (m6A) modification is implicated in cancer development, progression, and prognosis.
  • m6A regulators are emerging as novel targets for anticancer drug development.

Purpose of the Study:

  • To review the latest findings on m6A modification in cancer.
  • To summarize sources for discovering m6A-targeted anticancer agents.
  • To highlight the potential of artificial intelligence (AI) in this drug discovery process.

Main Methods:

  • Literature review of m6A modification in cancer.
  • Analysis of traditional medicine resources for m6A-targeting compounds.
  • Exploration of computer-based chemosynthetic compound discovery.
  • Discussion of AI-assisted drug discovery approaches.

Main Results:

  • m6A modification plays critical roles in various stages of cancer progression.
  • Traditional medicines and synthetic compounds offer rational sources for m6A-targeting agents.
  • AI presents a promising avenue for accelerating the discovery of m6A-targeting anticancer drugs.

Conclusions:

  • m6A-targeting agents hold significant potential for cancer treatment.
  • A multi-stage approach, including traditional medicine, chemical synthesis, and AI, can advance m6A-targeted drug discovery.
Keywords:
CancerChemosynthesisDrug discoveryModulatorsNatural productm6A

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