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Updated: Oct 3, 2025

A Modified Trier Social Stress Test for Vulnerable Mexican American Adolescents
Published on: July 10, 2017
Inter-relationships between changes in stress, mindfulness, and dynamic functional connectivity in response to a
James Teng1, Stijn A A Massar1, Julian Lim2,3
1Centre for Sleep and Cognition, Yong Loo Lin School of Medicine, National University of Singapore, Tahir Foundation Building, MD1, Level 13 South, 12 Science Drive 2, Singapore, 117549, Singapore.
Abstract:
We conducted a study to understand how dynamic functional brain connectivity contributes to the moderating effect of trait mindfulness on the stress response. 40 male participants provided subjective reports of stress, cortisol assays, and functional MRI before and after undergoing a social stressor. Self-reported trait mindfulness was also collected. Experiencing stress led to significant decreases in the prevalence of a connectivity state previously associated with mindfulness, but no changes in two connectivity states with prior links to arousal. Connectivity did not return to baseline 30 min after stress. Higher trait mindfulness was associated with attenuated affective and neuroendocrine stress response, and smaller decreases in the mindfulness-related connectivity state. In contrast, we found no association between affective response and functional connectivity. Taken together, these data allow us to construct a preliminary brain-behaviour model of how mindfulness dampens stress reactivity and demonstrate the utility of time-varying functional connectivity in understanding psychological state changes.
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