Hospital-Based Prevalence, Electroencephalogram (EEG), and Neuroimaging Correlation in Seizures Among Children in
Swarnalata Das1, Pragyan Paramita2, Natabar Swain1
1Pediatrics, Kalinga Institute of Medical Sciences, Bhubaneshwar, IND.
Insights
Febrile seizures are common in children, and this study highlights their prevalence in India. Electroencephalogram (EEG) is recommended as the primary diagnostic tool for pediatric seizures, with MRI offering superior accuracy for complex febrile cases.
Area of Science:
- Pediatric Neurology
- Epileptology
- Diagnostic Imaging
Background:
- Febrile seizures are frequent in children, necessitating differentiation from central nervous system (CNS) infections.
- While epilepsy risk is elevated post-febrile seizure, data from developing nations like India is limited.
Purpose of the Study:
- To determine the hospital-based prevalence and types of seizures in children in India.
- To correlate seizure types with electroencephalogram (EEG) and neuroimaging findings.
Main Methods:
- Prospective observational study of children aged 2 months to 15 years admitted between September 2017 and September 2019.
- Inclusion of patients diagnosed with seizures, followed by neurological examination and analysis of neuroimaging reports.
Main Results:
- A hospital-based prevalence of 6% for seizures was observed in 1,192 out of 19,553 admitted children.
- Generalized seizure disorder was most common; abnormal EEG (60%), MRI (49%), and CT (47%) were noted.
- MRI demonstrated higher accuracy in detecting CNS abnormalities in partial and complex febrile seizures compared to CT.
Conclusions:
- Electroencephalogram (EEG) should be the standard diagnostic test for pediatric seizures.
- CT/MRI scans supplement EEG findings, with MRI being more accurate for complex febrile seizures.
Background:
Febrile seizures are very common in pediatric practice. We need to differentiate between febrile seizures and other seizures due to central nervous system (CNS) infection by various means of investigation. Though approximately 30% of patients with febrile seizure have later epilepsy and the risk is around 20% even if electroencephalogram (EEG), and neuro-imagings are normal. But data regarding this is laking in developing countries like India.
Aim:
The primary objective of this study is to determine the hospital-based prevalence among various types and etiologies of seizures in children admitted to the pediatric department in a teaching hospital of a developing country, India. Besides, the different types of seizures were correlated with the EEG and neuroimaging findings along with the acute onset of seizures among children.
Methods:
In this prospective observational study, children from two months to 15 years of age admitted to the Pediatrics Department, KIMS, Bhubaneswar in India between September 2017 and September 2019 were taken. The patients having seizures were included in the study based on the inclusion criteria. Neurological and systemic examinations of the children were recorded and the neuroimaging reports were analyzed.
Results:
A total of 19,553 patients aged two months to 15 years were admitted during the study period. Of that, 1,192 cases were diagnosed with febrile and unprovoked seizures. It was observed that the hospital-based prevalence of seizures among children in Odisha was 6%. Besides, it is found that generalized seizure disorder was the most common among the children. It was found that abnormal EEG, magnetic resonance imaging (MRI), and computed tomography (CT) brain in 60% (202/340), 49% (113/230), and 47% (136/288) of cases, respectively. MRI is a better modality of investigation in partial seizure cases 22 (64%) to detect CNS abnormality. Also, MRI of the brain is better in evaluating CNS abnormality in complex febrile cases 4 (31%) than CT brain (0%).
Conclusion:
The study concluded that EEG must be the standard modality of test for patients' diagnosis of seizure in children with seizures. CT/MRI scan can give a better supplement to the results but MRI findings are more accurate in cases of complex febrile seizures.
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