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Updated: Oct 3, 2025
07:41
Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device
Published on: July 20, 2022
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Does infection predispose to thrombosis during long-term ventricular assist device support?
Noelia Bouzas-Cruz1,2, Javier Castrodeza3, Oscar Gonzalez-Fernandez4
1Department of Cardiology, Hospital Clínico Universitario de Santiago de Compostela, Santiago de Compostela, Spain.
Artificial Organs
|February 15, 2022
Summary
Infections and thrombotic events are common in patients with HeartWare Ventricular Assist Devices (HVADs). While related to support duration, infections do not clearly predispose to thrombotic events in HVAD recipients.
Area of Science:
- Cardiology
- Medical Devices
- Infectious Diseases
Background:
- Ventricular assist devices (VADs) are crucial for managing heart failure.
- Infections and thrombotic events are significant, life-threatening complications in VAD patients.
Purpose of the Study:
- To investigate the relationship between infections and thrombotic events in patients with HeartWare VAD (HVAD).
- To analyze the incidence and interplay of these adverse events in a VAD cohort.
Main Methods:
- Retrospective analysis of 220 patients who received HVAD implantation.
- Data collected from July 2009 to March 2019 at Freeman Hospital, UK.
- Examination of infection and thrombotic event occurrences and their correlation.
Main Results:
- Infection was the most frequent adverse event (56.8%), followed by pump thrombosis (27.7%).
- Of patients with infection, 53% also experienced a thrombotic event.
- While both events correlated with support duration, evidence for infection predisposing to thrombosis was limited.
Conclusions:
- Infection and thrombotic events are significant adverse events associated with HVAD support duration.
- Infections do not appear to be a clear predisposing factor for thrombotic events in HVAD patients.
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