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Antiviral Therapeutics in Pediatric Transplant Recipients

William R Otto1, Abby Green2

  • 1Division of Infectious Diseases, Department of Pediatrics, The Children's Hospital of Philadelphia, 3401 Civic Center Boulevard, Philadelphia, PA 19104-4399, USA.

Infectious Disease Clinics of North America
|February 16, 2022
PubMed

Insights

Pediatric solid organ and hematopoietic stem cell transplant recipients are vulnerable to viral infections due to immune suppression. This review discusses current and future antiviral strategies for preventing and treating these infections in children.

Area of Science:

  • Immunology
  • Virology
  • Pediatric Medicine

Background:

  • Solid organ and hematopoietic stem cell transplant recipients require significant immune suppression.
  • This immunosuppression increases the risk of opportunistic viral infections.
  • Limited randomized controlled trials exist for pediatric viral infection treatment.

Purpose of the Study:

  • To review the prevention and treatment of viral infections in pediatric transplant recipients.
  • To discuss current antiviral therapies.
  • To explore novel agents for future pediatric use.

Main Methods:

  • Literature review of existing randomized controlled trials and clinical data.
  • Discussion of available antiviral drugs.
  • Exploration of emerging antiviral agents.

Main Results:

  • Current treatment protocols are often based on adult data.
  • Available antiviral drugs can be used for prevention and treatment.
  • Novel agents show promise for future pediatric applications.

Conclusions:

  • Pediatric transplant recipients face a high risk of viral infections.
  • Evidence-based treatment guidelines for children are needed.
  • Continued research into novel antiviral therapies is crucial for improving outcomes.

Keywords:
AntiviralHematopoietic stem cell transplantHerpesvirusImmunocompromised hostPediatricsSolid organ transplantViral infection

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