An integrative method to increase the reliability of conventional double emulsion method

Area of Science:

• Biomaterials Science
• Chemical Engineering
• Nanotechnology

Background:

• Polymeric microspheres are crucial for drug delivery and tissue engineering.
• Conventional double emulsion methods for microsphere fabrication are complex and yield wide size distributions.
• Improving microsphere production efficiency and control is essential for widespread application.

Purpose of the Study:

• To overcome the limitations of conventional double emulsion methods for polymeric microsphere fabrication.
• To develop a modified method for producing microspheres with predictable characteristics and narrow size distribution.
• To investigate the impact of fabrication parameters on microsphere size and surface morphology.

Main Methods:

• Modification of the conventional double emulsion method.
• Integration of a high-throughput inertial microfluidics device.
• Systematic investigation of fabrication parameters influencing microsphere properties.

Main Results:

• The modified method enhances performance without sacrificing production rate.
• Microspheres with controlled size and surface morphology were successfully fabricated.
• Incorporation with microfluidics resulted in a narrow size distribution of microspheres.

Conclusions:

• The proposed modified double emulsion method is a promising approach for mass production of polymeric microspheres.
• This technique offers improved control over microsphere size and morphology for advanced applications.
• The findings provide valuable insights for researchers seeking to fabricate tailored microspheres.