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Published on: January 29, 2018
A unique case of death by MDPHP with no other co-ingestion: a forensic toxicology case
Domenico Di Candia1, Michele Boracchi2, Barbara Ciprandi1
1Dipartimento Di Scienze Biomediche Per La Salute-Sezione Di Medicina Legale E Delle Assicurazioni, Università Degli Studi Di Milano, via Luigi Mangiagalli, 37, 20133, Milan, Italy.
Abstract:
Synthetic cathinones are a class of psychoactive drugs that have become, in recent years, of quite common observation in medical and toxicological forensic field. MDPHP (3,4-methylenedioxy-α-pyrrolidinohexanophenone) belongs to this class of substances but lethal acute intoxication caused by this specific substance without other co-ingestions has never been described in literature. We are presenting the unique case of a fatal acute intoxication caused by MDPHP in a 48-year-old man carried to the A&E department of a big Milanese hospital where he suddenly deceased after brief time. Clinical records, autopsy examination, histological findings, and toxicological analysis, assessed via a Q-Exactive Orbitrap with a HPLC system and LC/MS-MS system, are discussed. This case report may represent the first case of this type of intoxication and might help in improving recognition and treatment of these particular cases.
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