Clinically relevant DNA viruses in pregnancy.

Area of Science:

• Maternal-fetal medicine
• Virology
• Genetics

Background:

• Pregnancy infections by DNA viruses can lead to severe health risks for both mother and fetus.
• Some DNA viruses can directly infect the fetus or cause placental dysfunction, increasing pregnancy complications.

Purpose of the Study:

• To introduce commonly detected DNA viruses in cell-free DNA sequencing during pregnancy.
• To discuss the pathogenic potential of these viruses on feto-maternal health.
• To highlight the role of Non-Invasive Prenatal Testing in early viral detection.

Main Methods:

• Review of literature on DNA viruses and pregnancy.
• Analysis of cell-free DNA sequencing data for viral DNA detection.
• Discussion of pathogenic mechanisms and clinical implications.

Main Results:

• Several DNA viruses are frequently detected in human cell-free DNA during pregnancy.
• These viruses exhibit varying degrees of pathogenic potential affecting feto-maternal outcomes.
• Non-Invasive Prenatal Testing shows promise for early identification of viral infections.

Conclusions:

• Awareness of DNA virus impact on feto-maternal health is crucial.
• Non-Invasive Prenatal Testing can facilitate early screening for viral DNA.
• Further research into treatment options is warranted given the potential for rapid advancements.