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Systemic sarcoidosis presenting as acute rapidly progressive proptosis
Maria Valeria da Silva1, Yael Chavez1, Maria Laura Di Nicola1
1Ocular Oncology Service, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
Arquivos Brasileiros De Oftalmologia
|February 16, 2022
Summary
Sarcoidosis, a chronic inflammation, can rarely affect the orbit, causing acute proptosis. This case highlights rapid orbital mass growth as an initial sign, resolving with corticosteroid therapy.
Area of Science:
- Ophthalmology
- Rheumatology
- Pathology
Background:
- Sarcoidosis is a systemic inflammatory disease characterized by granuloma formation.
- Orbital involvement in sarcoidosis is uncommon, often presenting insidiously.
- Rapidly progressive orbital masses mimicking malignancy are rare presentations.
Observation:
- A patient presented with acute proptosis due to a rapidly enlarging orbital mass.
- The orbital mass's rapid growth and appearance suggested a malignant tumor.
- Biopsy confirmed the mass as a manifestation of systemic sarcoidosis.
Findings:
- This case represents the first recognized presentation of systemic sarcoidosis as an acute orbital mass.
- The patient experienced complete resolution of proptosis and systemic sarcoidosis symptoms.
- Long-term corticosteroid treatment was effective in managing the condition.
Implications:
- Highlights the importance of considering sarcoidosis in the differential diagnosis of acute orbital masses.
- Demonstrates the efficacy of corticosteroid therapy in managing acute orbital sarcoidosis.
- Emphasizes the potential for sarcoidosis to present with atypical, rapidly progressive orbital manifestations.
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