Related Experiment Video
Updated: Oct 3, 2025

Iterative Optimization of DNA Duplexes for Crystallization of SeqA-DNA Complexes
Published on: November 1, 2012
Anhydrous calcium phosphate crystals stabilize DNA for dry storage
Philipp L Antkowiak1, Julian Koch1, Przemyslaw Rzepka1,2
1Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, Vladimir-Prelog-Weg 1, 8093 Zürich, Switzerland. robert.grass@chem.ethz.ch.
Abstract:
The resilience of ancient DNA (aDNA) in bone gives rise to the preservation of synthetic DNA with bioinorganic materials such as calcium phosphate (CaP). Accelerated aging experiments at elevated temperature and humidity displayed a positive effect of co-precipitated, crystalline dicalcium phosphate on the stability of synthetic DNA in contrast to amorphous CaP. Quantitative PXRD in combination with SEM and EDX measurements revealed distinct CaP phase transformations of calcium phosphate dihydrate (brushite) to anhydrous dicalcium phosphate (monetite) influencing DNA stability.
Related Concept Videos
DNA Packaging
Diversity of Archaea III
Restarting Stalled Replication Forks
The Nucleosome
DNA is wound twice around a protein complex called histone core, that consist of 8 histone proteins. This complex...
Diversity of Archaea IV
The DNA Helix

