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Tension Gauge Tether Probes for Quantifying Growth Factor Mediated Integrin Mechanics and Adhesion
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Dual clathrin and integrin signaling systems regulate growth factor receptor activation

Marco A Alfonzo-Méndez1, Kem A Sochacki1, Marie-Paule Strub1

  • 1Biochemistry and Biophysics Center, National Heart, Lung, and Blood Institute, National Institutes of Health, 50 South Drive, Building 50, Bethesda, MD, 20892, USA.

Nature Communications
|February 17, 2022
PubMed
Summary

Clathrin lattices organize growth factor and adhesion signals, linking epidermal growth factor receptor (EGFR) and β5-integrin. This crosstalk enhances cell signaling, impacting cancer progression and endocytosis.

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