Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

739
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
739
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

870
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
870
Glaucoma: Overview01:25

Glaucoma: Overview

945
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
945

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Autograft versus Allograft in Indirect Corneal Neurotization: A Systematic Review.

American journal of ophthalmology·2026
Same author

Gender Disparities in Thyroid Cancer Diagnosis: Evaluating Detection Bias and Clinical Implications.

The American surgeon·2026
Same author

Mezigdomide, carfilzomib, and dexamethasone versus carfilzomib and dexamethasone in patients with relapsed or refractory multiple myeloma (SUCCESSOR-2): a phase 3, open-label, randomised controlled trial.

Lancet (London, England)·2026
Same author

A cost-effectiveness analysis of medications compared with selective laser trabeculoplasty in patients with newly diagnosed open-angle glaucoma.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2026
Same author

Age-related macular degeneration associated with glucagon-like peptide-1 receptor agonist use: a systematic review.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2026
Same author

Diabetic macular edema and GLP-1 receptor agonist use: a systematic review and meta-analysis.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2026

Related Experiment Video

Updated: Oct 3, 2025

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.2K

Repeat Selective Laser Trabeculoplasty for Glaucoma Patients: A Systematic Review and Meta-analysis.

Hyunsoo J Jang1, Brian Yu1, William Hodge2

  • 1Department of Physiology and Pharmacology, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, Ontario, Canada.

Journal of Current Glaucoma Practice
|February 17, 2022
PubMed
Summary

Repeat selective laser trabeculoplasty (SLT) effectively lowers intraocular pressure (IOP) in primary open-angle glaucoma (POAG) patients for up to 24 months. Further research is needed to confirm the efficacy of multiple repeat SLT procedures.

Keywords:
GlaucomaIntraocular pressureLaserMeta-analysisRepeat selective laser trabeculoplastySelective laser trabeculoplastySystematic reviewTrabeculoplasty

More Related Videos

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.5K
Ultrasound Cyclo Plasty in Eyes with Glaucoma
05:05

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

12.3K

Related Experiment Videos

Last Updated: Oct 3, 2025

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

13.2K
Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis
13:47

Laser Capture Microdissection of Highly Pure Trabecular Meshwork from Mouse Eyes for Gene Expression Analysis

Published on: June 3, 2018

9.5K
Ultrasound Cyclo Plasty in Eyes with Glaucoma
05:05

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

12.3K

Area of Science:

  • Ophthalmology
  • Glaucoma Research
  • Laser Therapy

Background:

  • Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness.
  • Selective laser trabeculoplasty (SLT) is a common treatment for lowering intraocular pressure (IOP).
  • The efficacy of repeat SLT procedures for sustained IOP reduction in POAG requires further investigation.

Purpose of the Study:

  • To systematically evaluate the effectiveness of repeat selective laser trabeculoplasty (SLT) in managing primary open-angle glaucoma (POAG).
  • To synthesize current evidence on IOP reduction following repeat SLT procedures.

Main Methods:

  • A systematic literature search was conducted across PubMed, CINAHL, and EMBASE, including grey literature.
  • Included studies measured IOP before and after repeat SLT in adult POAG patients.
  • A meta-analysis using random-effects models was performed on data from 12 selected articles.

Main Results:

  • The meta-analysis included data from 12 studies (3 prospective, 9 retrospective).
  • A random-effects model indicated a significant reduction in intraocular pressure (IOP) at 24 months following repeat SLT.
  • Repeat SLT demonstrated minimal complications and safety concerns.

Conclusions:

  • Repeat SLT is a potentially effective procedure for lowering IOP in glaucoma patients for up to 24 months.
  • The efficacy of third or subsequent SLT treatments requires further verification.
  • High-quality, long-term randomized controlled trials are needed to solidify conclusions on repeat SLT efficacy.