Current treatment modalities in granulomatous cheilitis

Area of Science:

• Dermatology
• Oral Medicine

Background:

• Granulomatous cheilitis (GC) is an under-recognized labial mucosa disorder, classified under orofacial granulomatosis.
• Current management strategies for GC yield variable outcomes, ranging from suboptimal to optimal results.

Purpose of the Study:

• To review and discuss diverse medical and surgical treatment modalities for granulomatous cheilitis.
• To consolidate information on successful interventions for GC management.

Main Methods:

• Comprehensive literature search of PubMed and Google Scholar for successful GC treatments.
• Analysis of case reports and case series due to lack of systematic reviews or meta-analyses.
• Consolidation of recent data on various applied treatments for GC.

Main Results:

• Treatment options for GC include glucocorticoids, antibiotics, immunomodulatory agents, biological agents, surgical debulking, and laser therapy.
• No single treatment modality has demonstrated predictable success in managing GC.
• Intralesional corticosteroid therapy is a frequently employed treatment, used independently or adjunctively.

Conclusions:

• The management of granulomatous cheilitis is challenging, with varied responses to existing therapies.
• Intralesional corticosteroids represent a common therapeutic approach in GC treatment protocols.