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Related Concept Videos

Liver Physiology01:30

Liver Physiology

1.6K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
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Liver Histology01:27

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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
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Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

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The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
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Liver Regeneration01:24

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
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Updated: Oct 3, 2025

Hepatocyte-specific Ablation in Zebrafish to Study Biliary-driven Liver Regeneration
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Liver zonation, revisited.

Jasmin Paris1, Neil C Henderson1,2

  • 1Centre for Inflammation ResearchThe Queen's Medical Research InstituteEdinburgh BioQuarterUniversity of EdinburghEdinburghUK.

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Summary
This summary is machine-generated.

New single-cell technologies are revealing the complex organization of liver zonation. This enhanced understanding of hepatocyte function promises to drive precision medicine for liver disease patients.

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Area of Science:

  • Hepatology and molecular biology

Background:

  • Hepatocyte functional zonation, crucial for liver metabolism and xenobiotic processing, is influenced by factors like oxygen and nutrient gradients.
  • Traditional understanding of liver zonation is being revolutionized by advanced single-cell genomics and spatial profiling techniques.

Purpose of the Study:

  • To discuss how cutting-edge experimental strategies are dissecting liver zonation at unprecedented resolution.
  • To highlight the potential of this new knowledge in developing precision medicine therapies for liver diseases.

Main Methods:

  • Single-cell and single-nucleus RNA sequencing.
  • Spatial transcriptomic and proteomic profiling.

Main Results:

  • These technologies provide a high-resolution view of cellular heterogeneity within the liver lobule.
  • Detailed mapping of gene and protein expression patterns across the hepatic lobule.

Conclusions:

  • Advanced single-cell and spatial omics technologies are transforming the study of liver zonation.
  • This deeper understanding is expected to pave the way for novel precision medicine approaches for liver disease treatment.