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As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
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Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
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The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
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[Neuralgic amyotrophy].

S I Dedaev1, E S Druzhinina2, D S Druzhinin3

  • 1Soloviev Moscow Research and Clinical Center for Neuropsychiatry, Moscow, Russia.

Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova
|February 17, 2022
PubMed
Summary

This review synthesizes current knowledge on neuralgic amyotrophy, covering its causes, development, diverse presentations, and diagnostic and management strategies for affected patients.

Keywords:
dysimmune neuropathyneuralgic amyotrophyneuropathic pain

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Area of Science:

  • Neurology
  • Clinical Medicine

Background:

  • Neuralgic amyotrophy, also known as Parsonage-Turner syndrome, is an idiopathic neuropathy.
  • It is characterized by acute, severe nerve pain followed by muscle weakness and atrophy.

Purpose of the Study:

  • To provide a comprehensive overview of neuralgic amyotrophy.
  • To consolidate information on etiology, pathogenesis, atypical forms, diagnosis, and management.

Main Methods:

  • Literature review of existing studies on neuralgic amyotrophy.
  • Synthesis of data on disease characteristics and clinical practice.

Main Results:

  • Detailed discussion on the various factors contributing to neuralgic amyotrophy.
  • Exploration of the pathogenesis and different clinical manifestations.
  • Overview of diagnostic approaches and current treatment guidelines.

Conclusions:

  • Neuralgic amyotrophy presents a complex clinical picture requiring thorough diagnostic evaluation.
  • Effective management strategies are crucial for patient recovery and improved outcomes.