Correlation between hypo-pituitarism and poor cognitive function using neuropsychological tests after aneurysmal...

Area of Science:

• Neuroendocrinology
• Neurology
• Cognitive Science

Background:

• Hypopituitarism is a potential complication after aneurysmal subarachnoid hemorrhage (aSAH).
• The prevalence and impact of hypopituitarism on functional outcomes post-aSAH are not well-established.
• This study investigates the relationship between hypopituitarism and cognitive performance in aSAH patients.

Purpose of the Study:

• To correlate the presence of hypopituitarism with cognitive function in patients following aSAH.
• To assess the utility of neuropsychological tests in identifying neuroendocrine dysfunction post-aSAH.

Main Methods:

• A prospective cohort study involving 25 aSAH patients.
• Basal pituitary hormone testing was performed.
• Cognitive assessments using Montreal Cognitive Assessment (MoCA) and Mini Mental Status Examination (MMSE) were conducted at three time points: subacute (2 weeks), chronic (3-6 months), and follow-up (6-12 months).

Main Results:

• In the subacute phase, cognitive scores (MMSE, MoCA) were associated with low free triiodothyronine (fT3), luteinizing hormone (LH), follicle-stimulating hormone (FSH), and testosterone.
• In the chronic phase, cognitive scores correlated with low free thyroxine (fT4), LH, and FSH.
• In the follow-up phase, cognitive performance remained associated with low fT4, LH, and FSH.

Conclusions:

• Neuropsychological tests, such as MoCA and MMSE, are valuable and cost-effective tools for detecting cognitive impairment in aSAH patients.
• Cognitive deficits identified by these tests can indicate underlying neuroendocrine dysfunction in the post-acute phase.
• Early identification of hypopituitarism through cognitive assessment may aid in patient management.