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Related Concept Videos

Other Pulmonary Disorders01:17

Other Pulmonary Disorders

926
Respiratory disorders encompass a range of conditions with varying levels of severity. Asthma, marked by chronic airway inflammation and hypersensitivity, is one such condition. It can lead to airway obstruction due to factors like bronchial spasms, mucosal edema, increased mucus secretion, or epithelial damage. Asthma triggers are diverse, ranging from allergens to emotional upset, and treatment focuses on both immediate relief through bronchodilators and long-term inflammation suppression.
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Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

3.0K
Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
3.0K
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

378
Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
378
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

3.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
3.2K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

312
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
312
Trachea01:22

Trachea

2.9K
The trachea, commonly known as the windpipe, is a vital part of the human respiratory system. It serves as a passageway for air to travel between the larynx and the bronchi, allowing oxygen to reach the lungs. Let's explore its anatomical features, dimensions, layers of the tracheal wall, associated muscles, and the functions of its parts.
Anatomical Features:
Location: About half of the trachea is situated in the neck, anterior to the esophagus, and extends from the larynx (at the level of...
2.9K

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Updated: Oct 3, 2025

Author Spotlight: Investigating the Key Factors of Obliterative Bronchiolitis After Lung Transplantation
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Airway disease in hematologic malignancies.

Ricardo J José1,2, Burton F Dickey3, Ajay Sheshadri3

  • 1Department of Respiratory Medicine, Host Defence, Royal Brompton Hospital, Chelsea, London, UK.

Expert Review of Respiratory Medicine
|February 18, 2022
PubMed
Summary

Hematologic malignancies can cause serious airway diseases like viral bronchiolitis and bronchiectasis. Early identification and treatment are crucial for improving patient outcomes and survival rates.

Keywords:
Hematologic malignancyairway diseasebronchiectasisbronchiolitis obliterans syndromegraft versus host diseaseviral bronchitis

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Area of Science:

  • Pulmonology
  • Hematology
  • Oncology

Background:

  • Hematologic malignancies affect all ages, with treatments like chemotherapy and stem cell transplantation causing pulmonary complications.
  • Increased survival rates and novel therapies lead to a rise in secondary immunodeficiency, airway diseases, and respiratory infections.

Purpose of the Study:

  • To review viral bronchitis, Bronchiolitis Obliterans Syndrome (BOS), and bronchiectasis in patients with hematologic malignancies.
  • To highlight the significant impact of airway diseases on hematologic malignancy patients.

Main Methods:

  • Literature review of studies on viral bronchitis, BOS, and bronchiectasis in hematologic malignancy patients.
  • Searched PubMed for relevant literature.

Main Results:

  • Viral bronchiolitis, BOS, and bronchiectasis are common respiratory issues in hematologic malignancy.
  • Airway diseases significantly impact the quality of life and survival of these patients.

Conclusions:

  • Improved understanding of pathogenesis and treatment for viral bronchiolitis, BOS, and bronchiectasis is necessary.
  • Early identification strategies can improve treatment efficacy, slow lung function decline, and enhance quality of life for survivors.