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Electrochemotherapy of Tumours

Electrochemotherapy of Tumours

Published on: December 15, 2008

Electrochemotherapy treatment safety under parallel needle deflection.

Daniella L L S Andrade¹, Raul Guedert¹, Guilherme B Pintarelli¹

¹Institute of Biomedical Engineering, Federal University of Santa Catarina, Florianópolis, 88040-900, Brazil.

Scientific Reports

|February 18, 2022

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Deflected electrodes in electrochemotherapy (ECT) pose significant risks. A deflection of ±2 mm is unsafe, potentially causing dangerous currents or treatment blind spots, compromising cancer treatment efficacy.

Area of Science:

Biomedical Engineering
Oncology
Veterinary Medicine

Background:

Electrochemotherapy (ECT) relies on precise electric fields for cancer treatment.
Electrode damage, specifically deflection, can compromise the electric field distribution and treatment effectiveness.
Reusing needle electrodes in veterinary ECT has been linked to mechanical deformations like tip misshaping and deflection.

Purpose of the Study:

To evaluate potential problems and treatment pitfalls associated with ESOPE type II electrode deflection.
To investigate if electroporation models can describe electrode deflection failure.
To compare in vitro and in silico experimental results using vegetal and tumor models.

Main Methods:

Performed in vitro experiments to assess electrode deflection.

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Developed and utilized in silico models (electroporation model) for simulation.

Compared experimental and simulation data using potato tuber (Solanum tuberosum) and tumor models.

Main Results:

Electrode deflection significantly impacts the electric field distribution essential for ECT.
A deflection of ±2 mm was identified as unsafe for ECT treatment.
Inward deflection can lead to dangerously high electrical current levels in tumors, not accurately predicted by vegetal models.
Outward deflection can create "blind spots" in the electric field coverage.

Conclusions:

Deflected electrodes are not recommended for electrochemotherapy.
Electrode integrity is critical for safe and effective ECT delivery.
Current in silico models, particularly those based on vegetal tissues, may not fully capture the complexities of deflection-induced failures in conductive tumor tissues.