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Musa acuminata as electroporation model.

Daniella L L S Andrade1, Guilherme B Pintarelli2, Juliana V Rosa1

  • 1Institute of Biomedical Engineering, Department of Electrical and Electronics Engineering, Federal University of Santa Catarina, Florianópolis, SC, Brazil.

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|August 28, 2023
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Summary

Cavendish banana tissue offers a rapid, reliable alternative to potato phantoms for electroporation (EP) studies. This Musa acuminata model quickly evaluates electric field distribution, aiding cancer treatment development.

Keywords:
Cavendish bananaMathematical modelingNonlinear phenomenaPEF treatmentTissue-mimicking phantom

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Area of Science:

  • Biophysics
  • Biomaterials
  • Medical Engineering

Background:

  • Electrochemotherapy (ECT) and Irreversible electroporation (IRE) are electric field-based cancer therapies.
  • Accurate tissue conductivity modeling is crucial for treatment planning and hardware development.
  • Solanum tuberosum (potato) phantoms are used to mimic tissue electrical properties during electroporation (EP).

Purpose of the Study:

  • To develop and validate a Musa acuminata (Cavendish banana) conductivity model as a rapid alternative to potato phantoms for EP studies.
  • To investigate the frequency response, conductivity changes, and electric field distribution in banana tissue during EP.
  • To optimize mathematical models for describing EP in biological tissues.

Main Methods:

  • Impedance spectroscopy analysis to determine dielectric parameters of banana tissue.
  • Enzymatic staining to visualize and assess electroporated areas.
  • Optimization of adapted Gompertz, smoothed Heaviside, and sigmoid/logistic functions to model EP.
  • Comparison of electrical conductivity and permittivity of banana tissue with potato tissue.

Main Results:

  • Banana tissue exhibited dielectric parameters similar to potato, with electrical conductivity of 0.035 S/m and relative permittivity of 4.1×10^4.
  • Optimized EP models showed high coefficients of determination (R² > 99.5%), with sigmoid and Heaviside functions accurately describing electric currents.
  • Electroporated areas in bananas were observable within 3.5 hours post-EP, with significant staining at 450 V/cm.

Conclusions:

  • Musa acuminata (Cavendish banana) serves as a reliable, fast-acting phantom for electroporation studies, offering significant time savings over potato.
  • The developed banana conductivity model is suitable for treatment planning, hardware development, and training in EP.
  • Banana phantoms support the 3Rs principles (Replacement, Reduction, Refinement) in animal research and provide a viable alternative for EP studies.