Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

2.6K
Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult...
2.6K
The Tumor Microenvironment02:17

The Tumor Microenvironment

6.8K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.8K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Abnormal Proliferation02:23

Abnormal Proliferation

4.7K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

SubGE-DDI: A new prediction model for drug-drug interaction established through biomedical texts and drug-pairs knowledge subgraph enhancement.

PLoS computational biology·2024
Same author

Graph-DTI: A New Model for Drug-target Interaction Prediction Based on Heterogenous Network Graph Embedding.

Current computer-aided drug design·2023
Same author

Gut microbiota and neonatal acute kidney injury biomarkers.

Pediatric nephrology (Berlin, Germany)·2023
Same author

Systematic evaluation of the prognostic and immunological role of PDLIM2 across 33 cancer types.

Scientific reports·2022
Same author

An Evolutionary Frog Leaping Algorithm for Global Optimization Problems and Applications.

Computational intelligence and neuroscience·2021
Same author

Study on the Mechanism of Liuwei Dihuang Pills in Treating Parkinson's Disease Based on Network Pharmacology.

BioMed research international·2021

Related Experiment Video

Updated: Oct 3, 2025

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.4K

Prognostic and Immunological Roles of MMP-9 in Pan-Cancer.

Yudan Zeng1, Mengqian Gao1, Dongtao Lin1

  • 1School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.

Biomed Research International
|February 18, 2022
PubMed
Summary
This summary is machine-generated.

Matrix metalloproteinase-9 (MMP-9) impacts cancer prognosis and metastasis. This study reveals MMP-9

More Related Videos

Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

544
A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
09:00

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

868

Related Experiment Videos

Last Updated: Oct 3, 2025

An Orthotopic Murine Model of Human Prostate Cancer Metastasis
06:48

An Orthotopic Murine Model of Human Prostate Cancer Metastasis

Published on: September 18, 2013

35.4K
Development of Compendium for Esophageal Squamous Cell Carcinoma
03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

544
A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions
09:00

A Streamlined Approach for Mass Spectrometry-Based Proteomics Using Selected Tissue Regions

Published on: April 18, 2025

868

Area of Science:

  • Oncology
  • Immunology
  • Genomics

Background:

  • Matrix metalloproteinase-9 (MMP-9) degrades extracellular matrix, aiding tumor progression.
  • MMP-9's role in immune cell interactions is noted in various cancers.
  • Comprehensive pan-cancer studies on MMP-9's prognostic and immune infiltration roles are lacking.

Purpose of the Study:

  • To comprehensively analyze MMP-9's differential expression in normal versus cancerous tissues.
  • To investigate the prognostic significance of MMP-9 across diverse tumor types.
  • To explore the correlation between MMP-9 expression, immune infiltration, and genomic instability.

Main Methods:

  • Utilized TCGA and GTEx databases for differential expression analysis.
  • Performed survival analysis and assessed MMP-9 expression across clinical stages.
  • Correlated MMP-9 with immune-associated genes, immunocytes, tumor mutation burden (TMB), and DNA repair genes.

Main Results:

  • MMP-9 significantly impacts cancer prognosis and metastasis, affecting survival and clinical stage in multiple tumors.
  • MMP-9 expression correlates with immune cell markers (T cells, macrophages, Th1 cells, T cell exhaustion) and DNA repair genes.
  • MMP-9 is associated with TMB and DNA microsatellite instability in several cancer types.

Conclusions:

  • MMP-9 is linked to pan-cancer immune infiltration and serves as a biomarker for cancer prognosis and metastasis.
  • Findings offer potential prognostic molecular markers and insights for cancer immunotherapy.