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Updated: Oct 3, 2025
09:10
siRNA Electroporation to Modulate Autophagy in Herpes Simplex Virus Type 1-Infected Monocyte-Derived Dendritic Cells
Published on: October 28, 2019
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[Autophagy modulation by viruses: An important role in tumor progression]
Lucas Leonardi1, Sophie Sibéril1, Marco Alifano2
1Inserm UMRS1138, Centre de recherche des Cordeliers, 15 rue de l'École de médecine, 75006 Paris, France - Sorbonne université, Univ Paris 6, France.
Medecine Sciences : M/S
|February 18, 2022
Summary
Autophagy, a cellular process, plays a dual role in cancer. Viral infections can alter autophagy, significantly impacting tumor progression and treatment resistance.
Area of Science:
- Cell Biology
- Oncology
- Virology
Background:
- Autophagy is crucial for cellular homeostasis, development, and stress response.
- Autophagy influences cancer by limiting early-stage transformation but promoting advanced tumor growth, metastasis, and therapy resistance.
- Viral infections modulate autophagy, affecting viral replication and host cell survival.
Purpose of the Study:
- To review recent findings on how viral infection-induced autophagy alterations impact tumor behavior.
Main Methods:
- Literature review of studies investigating autophagy modulation by viral infections in cancer models.
Main Results:
- Viral infection-induced autophagy changes significantly affect tumor progression.
- The specific impact of autophagy modulation by viruses on tumors is context-dependent.
Conclusions:
- Understanding the interplay between viral infections, autophagy, and cancer is critical for developing novel therapeutic strategies.
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