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CHARACTERISTICS OF CERTAIN INDICES OF MINERAL METABOLISM IN CHILDREN WITH KIDNEY CALCULI

Iryna S Lembryk1, Oksana V Tymoshchuk1, Lesia Ya Ivanyshyn1

  • 1IVANO-FRANKIVSK NATIONAL MEDICAL UNIVERSITY, IVANO-FRANKIVSK, UKRAINE.

Wiadomosci Lekarskie (Warsaw, Poland : 1960)
|February 19, 2022
PubMed

Insights

Children with kidney stones, particularly oxalate-calcium nephropathy, show significant bone density issues. These findings highlight a risk for osteopenic syndrome in affected children.

Area of Science:

  • Pediatric Nephrology
  • Bone Metabolism
  • Urolithiasis Research

Background:

  • Kidney calculi are a growing concern in pediatric populations.
  • Bone density disturbances are increasingly recognized in children with urolithiasis.

Purpose of the Study:

  • To investigate bone density index abnormalities in pediatric patients diagnosed with kidney calculi.
  • To identify specific metabolic and developmental factors associated with bone density changes in these children.

Main Methods:

  • Evaluated 175 children with kidney calculi using biochemical analysis, ultrasonography, voiding cystourethrography, and excretory urography.
  • Assessed bone mineral density via ultrasonic densitometry.
  • Analyzed data using standard statistical methods.

Main Results:

  • Oxaluria and oxalate-calcium nephropathy were prevalent (60.0% and 30.0%, respectively).
  • Signs of connective tissue dysplasia were observed in 50.0% of patients.
  • Children with oxalate-calcium nephropathy exhibited elevated bone alkaline and acid phosphatase isoenzymes, decreased ionized calcium, hypomagnesemia, and hypophosphatemia.

Conclusions:

  • Children diagnosed with oxalate-calcium nephropathy are at high risk for developing osteopenic syndrome.
  • Early detection and management of bone metabolism disturbances are crucial in pediatric kidney stone patients.
Abstract

Keywords:
childrenbone densitykidney calculi

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