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Related Concept Videos

Necrosis01:16

Necrosis

4.9K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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Related Experiment Video

Updated: Oct 3, 2025

Optic Nerve Transection: A Model of Adult Neuron Apoptosis in the Central Nervous System
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Periorbital necrotizing fasciitis.

Edward J Wladis1

  • 1Lions Eye Insitute, Department of Ophthalmology, Albany Medical College, Slingerlands, NY 12159, USA.

Survey of Ophthalmology
|February 20, 2022
PubMed
Summary

Periorbital necrotizing fasciitis is a dangerous emergency requiring rapid clinical recognition and treatment. Early diagnosis and thorough management are crucial to prevent vision loss, eye loss, and death.

Area of Science:

  • Ophthalmology
  • Infectious Disease
  • Emergency Medicine

Background:

  • Periorbital necrotizing fasciitis is a rare but life-threatening infection with severe consequences.
  • High index of suspicion is critical for prompt diagnosis and intervention.

Purpose of the Study:

  • To review the key features, systemic effects, and treatment strategies for periorbital necrotizing fasciitis.
  • To emphasize the emergent nature of this condition and guide clinical management.

Main Methods:

  • Literature review of classic features, systemic implications, and management of periorbital necrotizing fasciitis.
  • Synthesis of current understanding and best practices for this condition.

Main Results:

  • Necrotizing fasciitis in the periorbital region presents significant risks including vision and life loss.
Keywords:
AntibioticDebridementExenterationMortalityNecrotizing fasciitisPeriorbital

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  • Rapid and comprehensive management is essential for favorable outcomes.

    • Conclusions:

    • Early recognition and aggressive treatment are paramount in managing periorbital necrotizing fasciitis.
    • Clinicians must be vigilant for this emergency to improve patient survival and preserve function.