Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hydrogen Bonds00:26

Hydrogen Bonds

127.0K
Hydrogen bonds are weak attractions between atoms that have formed other chemical bonds. One of these atoms is electronegative, like oxygen, and has a partial negative charge. The other is a hydrogen atom that has bonded with another electronegative atom and has a partial positive charge.
Hydrogen Bonds Control the World!
Because hydrogen has very weak electronegativity when it binds with a strongly electronegative atom, such as oxygen or nitrogen, electrons in the bond are unequally shared....
127.0K
Induced-fit Model01:13

Induced-fit Model

83.2K
Most chemical reactions in cells require enzymes—biological catalysts that speed up the reaction without being consumed or permanently changed. They reduce the activation energy needed to convert the reactants into products. Enzymes are proteins, that usually work by binding to a substrate—a reactant molecule that they act upon.
Enzymes exhibit substrate specificity, meaning that they can only bind to certain substrates. This is mainly determined by the shape and chemical...
83.2K
Coupled Reactions01:17

Coupled Reactions

8.7K
Cellular processes such as building and breaking down complex molecules occur through stepwise chemical reactions. Some of these chemical reactions are spontaneous and release energy, whereas others require energy to proceed. Cells often couple the energy-releasing reaction with the energy-requiring one to carry out important cell functions. 
Energy in adenosine triphosphate or ATP molecules is easily accessible to do work. ATP powers the majority of energy-requiring cellular reactions....
8.7K
Noncovalent Attractions in Biomolecules02:35

Noncovalent Attractions in Biomolecules

57.8K
Noncovalent attractions are associations within and between molecules that influence the shape and structural stability of complexes. These interactions differ from covalent bonding in that they do not involve sharing of electrons.
Four types of noncovalent interactions are hydrogen bonds, van der Waals forces, ionic bonds, and hydrophobic interactions.
Hydrogen bonding results from the electrostatic attraction of a hydrogen atom covalently bonded to a strong-electronegative atom like oxygen,...
57.8K
Cooperative Allosteric Transitions01:58

Cooperative Allosteric Transitions

8.1K
Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
8.1K
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

3.5K
Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
3.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surface Electrochemistry of Au(111) in Acetonitrile Based Electrolytes: Formation of a Solvent Related Adsorbed Layer.

The journal of physical chemistry letters·2026
Same author

Enhanced and selective oxygen reduction by iron porphyrin with a biguanide residue in the second coordination sphere.

Chemical science·2026
Same author

Proton-Coupled Electron and Energy Transfer in Molecular Triads.

Accounts of chemical research·2026
Same author

Proton and Electron Transfer Control of Selectivity in Electrochemical CO<sub>2</sub> Reduction: Selective Reduction of CO<sub>2</sub> to CO, CH<sub>4</sub>, and C<sub>2</sub>H<sub>6</sub> Catalyzed by the Same Iron Porphyrin.

Journal of the American Chemical Society·2026
Same author

A Simple Approach for Operando Interface Probing for Batteries: Combining Scanning APXPS with Spectroscopic Recognition.

ACS applied materials & interfaces·2026
Same author

A Highly Sensitive Water-Soluble Donor-Acceptor Dye for Early-Stage Amyloid Aggregation Kinetics.

The journal of physical chemistry. B·2026

Related Experiment Video

Updated: Oct 3, 2025

Protein Film Infrared Electrochemistry Demonstrated for Study of H2 Oxidation by a [NiFe] Hydrogenase
10:01

Protein Film Infrared Electrochemistry Demonstrated for Study of H2 Oxidation by a [NiFe] Hydrogenase

Published on: December 4, 2017

12.3K

A Bidirectional Bioinspired [FeFe]-Hydrogenase Model.

Md Estak Ahmed1, Abhijit Nayek1, Alenka Križan2

  • 1School of Chemical Sciences, Indian Association for the Cultivation of Science, 2A & 2B Raja S.C. Mullick Road, Jadavpur, Kolkata, India 700032.

Journal of the American Chemical Society
|February 21, 2022
PubMed
Summary

New iron-based catalysts inspired by [FeFe]-hydrogenase efficiently convert hydrogen and protons. These bioinspired catalysts are game-changers for sustainable energy and fuel cells.

More Related Videos

Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins
10:21

Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins

Published on: June 20, 2019

24.3K
Hydrogen Production and Utilization in a Membrane Reactor
10:00

Hydrogen Production and Utilization in a Membrane Reactor

Published on: March 10, 2023

2.6K

Related Experiment Videos

Last Updated: Oct 3, 2025

Protein Film Infrared Electrochemistry Demonstrated for Study of H2 Oxidation by a [NiFe] Hydrogenase
10:01

Protein Film Infrared Electrochemistry Demonstrated for Study of H2 Oxidation by a [NiFe] Hydrogenase

Published on: December 4, 2017

12.3K
Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins
10:21

Expression, Purification, Crystallization, and Enzyme Assays of Fumarylacetoacetate Hydrolase Domain-Containing Proteins

Published on: June 20, 2019

24.3K
Hydrogen Production and Utilization in a Membrane Reactor
10:00

Hydrogen Production and Utilization in a Membrane Reactor

Published on: March 10, 2023

2.6K

Area of Science:

  • Sustainable energy technologies
  • Electrocatalysis
  • Bioinorganic chemistry

Background:

  • Hydrogen (H2) technologies offer a sustainable energy future, but require efficient catalysts for fuel cells.
  • Platinum group metals are effective but expensive catalysts for H2 interconversion.
  • Bioinspiration provides a pathway to discover novel, cost-effective catalyst alternatives.

Purpose of the Study:

  • To develop novel, efficient, and cost-effective electrocatalysts for hydrogen interconversion.
  • To explore bioinspired catalysts based on the [FeFe]-hydrogenase active site.
  • To implement these catalysts in a functional membrane-less H2/O2 fuel cell.

Main Methods:

  • Design and synthesis of novel iron-based catalysts.
  • Electrochemical characterization of catalytic activity for H2 and proton interconversion.
  • Implementation of catalysts in a membrane-less H2/O2 fuel cell device.

Main Results:

  • A novel class of iron-based catalysts inspired by [FeFe]-hydrogenase demonstrated bidirectional electrocatalytic activity.
  • Efficient interconversion of H2 and protons was achieved under near-neutral aqueous conditions.
  • The bioinspired catalysts were successfully integrated into a functional membrane-less H2/O2 fuel cell.

Conclusions:

  • Bioinspired iron-based catalysts show promise as efficient and cost-effective alternatives to platinum group metals.
  • These catalysts can facilitate sustainable hydrogen energy systems and fuel cell applications.
  • The developed catalysts represent a significant advancement in electrocatalyst design for clean energy conversion.