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Vitamin D Levels in Patients with Behcet's Disease: A Systematic Review and Meta-Analysis

Kamila Hashemzadeh1, Maryam Rezazadeh1, Abolfazl Eftekhari2

  • 1Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.

Current Rheumatology Reviews
|February 21, 2022
PubMed

Insights

This study found that vitamin D levels are higher in Behcet's disease patients than in healthy controls. Increased vitamin D may be linked to a lower risk of active Behcet's disease.

Area of Science:

  • Rheumatology
  • Immunology
  • Endocrinology

Background:

  • Behcet's disease (BD) is a chronic, multisystem inflammatory disorder of unclear origin.
  • Vitamin D's role in inflammatory and autoimmune conditions is increasingly recognized.
  • This study investigates the association between vitamin D status and Behcet's disease activity.

Approach:

  • A systematic review and meta-analysis was conducted following PRISMA guidelines.
  • Included observational studies assessed 25(OH)D concentrations in Behcet's disease patients.
  • Data from 12 studies involving 1265 participants were analyzed.

Key Points:

  • Patients with active Behcet's disease exhibited significantly lower serum vitamin D levels compared to those with inactive disease.
  • Overall, Behcet's disease patients showed significantly higher serum vitamin D levels than healthy controls.
  • A total of 341 publications were initially screened, with 12 studies ultimately included in the meta-analysis.

Conclusions:

  • The findings support the hypothesis that higher serum vitamin D levels are associated with a reduced risk of active Behcet's disease.
  • Further research into vitamin D supplementation for Behcet's disease management is warranted.
Abstract

Keywords:
Behcet’s diseasegenital ulceroral aphthosisrheumatologyvasculitisvitamin D deficiency

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