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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

550
Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
550
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

69
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
69
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

536
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
536
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

86
Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
86

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Articles linked to this work by shared authors, journal, and citation graph.

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Intravenous Immunoglobulins in the Prevention of Rejection of a Second or Third Kidney Graft.

Transplantation proceedings·2018
Same author

Reduction of Extended-Release Tacrolimus Dose in Low-Immunological-Risk Kidney Transplant Recipients Increases Risk of Rejection and Appearance of Donor-Specific Antibodies: A Randomized Study.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
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Genome-Wide Association Study of Acute Renal Graft Rejection.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2016
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Mycophenolate mofetil in patients with anti-neutrophil cytoplasmic antibody-associated vasculitis: a prospective pharmacokinetics and clinical study.

Clinical and experimental immunology·2013
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Terminal complement inhibitor eculizumab in atypical hemolytic-uremic syndrome.

The New England journal of medicine·2013
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CMV infection in the donor and increased kidney graft loss: impact of full HLA-I mismatch and posttransplantation CD8(+) cell reduction.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2013

Related Experiment Video

Updated: Oct 3, 2025

Murine Full-thickness Skin Transplantation
07:59

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[Advances in transplantation: Conclusion].

Y Lebranchu1

  • 1Académie nationale de médecine, 16, rue Bonaparte, 75006 Paris, France.

Bulletin De L'Academie Nationale De Medecine
|February 21, 2022
PubMed
Summary

Organ transplantation has seen success, but new challenges require improved organ storage, updated infection strategies, understanding chronic rejection, and rethinking immunosuppression for better patient outcomes.

Keywords:
Chronic rejectionCovid-19Immunosuppressive strategiesOrgan storage

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Area of Science:

  • Immunology
  • Transplant Surgery
  • Infectious Disease

Context:

  • Organ transplantation has achieved remarkable success.
  • Recent advancements present new challenges in the field.
  • Emerging infectious diseases, like COVID-19, impact transplant recipients.

Purpose:

  • To address key challenges in organ transplantation.
  • To enhance organ quality through improved storage.
  • To adapt transplant strategies for new infectious threats.
  • To elucidate chronic rejection mechanisms, focusing on innate immunity.
  • To reformulate immunosuppressive therapies for prevention and treatment of chronic rejection.

Summary:

  • Improving harvested organ storage to enhance graft quality.
  • Adapting transplantation strategies to account for immunodeficiency and novel infections (e.g., SARS-CoV-2).
  • Investigating the role of innate immunity in chronic rejection.
  • Revising immunosuppressive protocols to manage and prevent chronic rejection.

Impact:

  • Potential for improved organ transplant success rates.
  • Enhanced patient safety in the context of new infectious diseases.
  • Advancements in understanding and combating chronic transplant rejection.
  • Development of more effective immunosuppressive treatments.