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[Valproic Acid Could Help in the Fight Against COVID-19: a case-control study]
Oscar Moreno-Pérez1,2, Esperanza Merino3, Jose Manuel Ramos4,2
1Endocrinology and Nutrition department, Alicante General University Hospital - Alicante Institute of Health and Biomedical Research (ISABIAL), Alicante, Spain.
Neurologia (Barcelona, Spain)
|February 21, 2022
Summary
Valproic acid (VPA) use within therapeutic range significantly reduced SARS-CoV-2 infection incidence by over 75%. VPA therapy also showed a trend toward lower COVID-19 hospitalization risk.
Area of Science:
- Pharmacology
- Infectious Diseases
- Epidemiology
Context:
- Early evidence suggested Valproic acid (VPA) possesses antiviral properties.
- The study investigated the impact of VPA on SARS-CoV-2 infection rates and severity.
Purpose:
- To determine the incidence and severity of SARS-CoV-2 infection in VPA users compared to the general population.
- To evaluate the association between VPA regimen adherence, therapeutic drug levels, and SARS-CoV-2 outcomes.
Summary:
- A case-control study analyzed SARS-CoV-2 infection and hospitalization data in VPA users versus non-users.
- Patients on VPA within the therapeutic range (ATR) exhibited a >75% reduction in SARS-CoV-2 infection incidence.
- A trend towards reduced COVID-19 hospital admissions was observed in VPA users.
Impact:
- Findings suggest VPA may offer protective effects against SARS-CoV-2 infection, particularly when maintained at therapeutic levels.
- Highlights the potential of repurposed drugs in managing viral infections.
- Warrants further clinical investigation into VPA's antiviral efficacy and safety profile.
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