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Nicotinamide N-Methyltransferase in Health and Cancer

David B Ramsden1, Rosemary H Waring2, David J Barlow3

  • 1Institute of Metabolism and Systems Research, The Medical School, University of Birmingham, Birmingham, UK.

International Journal of Tryptophan Research : IJTR
|February 21, 2022
PubMed

Insights

Nicotinamide N-methyltransferase (NNMT) and its product 1-methyl nicotinamide are crucial in human health and cancer. This review details their structure and role in common cancers.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Nicotinamide N-methyltransferase (NNMT) and 1-methyl nicotinamide were once considered minor players in xenobiotic metabolism.
  • Recent research highlights their significant involvement in critical human biological processes.

Purpose of the Study:

  • To review the structural aspects of the NNMT gene, messenger RNA, and protein.
  • To elucidate the role of NNMT in the development of common human cancers.

Main Methods:

  • Literature review of existing studies on NNMT.
  • Analysis of structural data for NNMT gene, mRNA, and protein.
  • Examination of NNMT's involvement in cancer pathways.

Main Results:

  • Detailed structural information of NNMT, its mRNA, and protein is presented.
  • NNMT's significant role in various common human cancers is discussed.

Conclusions:

  • NNMT and 1-methyl nicotinamide are key factors in human health and disease.
  • Understanding NNMT's structure and function is vital for cancer research and potential therapeutic strategies.
Keywords:
Energy metabolismcancerfatliver

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