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The relationship between thyroid function tests and sleep quality: cross-sectional study.

Mohammad Reza Nazem1, Ehsan Bastanhagh2, Ali Emami3

  • 1Department of Clinical Biochemistry, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.

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Summary
This summary is machine-generated.

Poor sleep quality significantly increases thyroid hormones, including free thyroxine (FT4) and thyroid-stimulating hormone (TSH). Low sleep quality also correlates with stress and elevated FT4 levels in medical students.

Keywords:
Pittsburgh Sleep Quality IndexSleep DeprivationTSH, T3, T4ThyroxineTriiodothyronine

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Area of Science:

  • Endocrinology
  • Sleep Medicine
  • Psychoneuroimmunology

Background:

  • Sleep quality profoundly impacts the endocrine system.
  • Previous research highlights the link between sleep and hormonal regulation.
  • This study investigates thyroid hormone levels in individuals with poor sleep.

Purpose of the Study:

  • To assess serum thyroid hormone concentrations (free T3, free T4, TSH) in medical students.
  • To compare thyroid hormone levels between groups with good and poor sleep quality.
  • To explore correlations between sleep quality, stress, and thyroid hormones.

Main Methods:

  • A descriptive, cross-sectional study involving 83 male medical students.
  • Participants were categorized into low (n=41) and good (n=42) sleep quality groups using the Pittsburgh Sleep Quality Index and ISMA Stress questionnaire.
  • Serum levels of free T3, free T4, and TSH were measured and compared.

Main Results:

  • Significantly elevated serum levels of free T4 (p=0.01) and TSH (p=0.02) were observed in the poor sleep group.
  • Meaningful correlations were found between sleep score and stress score (p=0.008) in the poor sleep group.
  • A significant correlation was also identified between stress score and FT4 levels (p=0.03) in the poor sleep group.

Conclusions:

  • Poor sleep quality is associated with significantly increased thyroid function tests, specifically T4 and TSH.
  • The findings suggest a potential impact of low sleep quality on thyroid hormone regulation.
  • Correlations between sleep, stress, and FT4 in the poor sleep group warrant further investigation into the interplay of these factors.