Practical Considerations for the Daratumumab Management in Portuguese Routine Clinical Practice: Recommendations From
Catarina Geraldes1,2,3, Manuel Neves4, Sérgio Chacim5
1Departamento de Hematologia Clínica, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal.
Frontiers in Oncology
|February 21, 2022
Summary
Daratumumab offers effective treatment for multiple myeloma (MM). Clinicians should manage potential adverse events like infections and hematological toxicity through careful monitoring and communication for optimal patient outcomes.
Area of Science:
- Hematology
- Oncology
- Pharmacology
Background:
- Recent advancements in multiple myeloma (MM) therapy include novel potent drug classes.
- Daratumumab, a CD38-targeting antibody, is effective in MM monotherapy and combination regimens.
- Treatment discontinuation due to adverse events impacts patient quality of life and outcomes.
Purpose of the Study:
- To guide clinicians on practical, real-world considerations for using daratumumab in MM treatment.
- To address potential complications and optimize patient care based on expert consensus.
Main Methods:
- An expert panel of Portuguese hematologists provided recommendations.
- Focus on practical considerations for daratumumab treatment in multiple myeloma.
- Emphasis on adherence to SmPC and combination regimen guidelines.
Main Results:
- Careful adherence to guidelines and interprofessional communication are crucial for preventing complications.
- Risk assessment for infection, patient education on adverse events, and prophylaxis/vaccination are recommended.
- Management of hematological toxicity may require therapeutic schedule delays.
- Daratumumab is effective in renal impairment with close monitoring and nephrology collaboration.
Conclusions:
- Daratumumab treatment requires careful management of potential adverse events to maximize efficacy and minimize safety risks.
- Sharing clinical practice enhances medical education for optimizing daratumumab therapy in multiple myeloma.
- Individualized patient assessment and proactive management are key to successful daratumumab treatment.
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