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Published on: January 20, 2019
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Large Animal Models of Breast Cancer
Pinaki Mondal1,2, Katie L Bailey1, Sara B Cartwright1
1Department of Surgery, University of Nebraska Medical Center, Omaha, NE, United States.
Frontiers in Oncology
|February 21, 2022
Summary
Large animal models, including canine, feline, and porcine subjects, offer advantages for breast cancer (BC) research. These models provide human-sized subjects and greater biological relevance compared to rodent models.
Area of Science:
- Oncology
- Comparative Medicine
- Veterinary Science
Background:
- Breast cancer (BC) research extensively uses rodent models.
- Limitations of rodent models include size and biological relevance.
- Large animal models offer potential to overcome these limitations.
Purpose of the Study:
- To review the status, advantages, and disadvantages of large animal models for breast cancer research.
- To compare large animal models with established rodent models.
- To highlight the potential of emerging porcine models.
Main Methods:
- Literature review of studies utilizing canine, feline, and porcine subjects for breast cancer modeling.
- Brief review of commonly used rodent breast cancer models for contextualization.
- Analysis of the benefits and drawbacks of large animal models.
Main Results:
- Canine and feline models have been historically used.
- Porcine models show early promise for modeling human breast cancer.
- Large animal models offer human-sized subjects and enhanced biological relevance.
Conclusions:
- Large animal models represent valuable additions to breast cancer research tools.
- Porcine models are an emerging area with significant potential.
- Further development of large animal models can advance breast cancer understanding and treatment.
