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Updated: Oct 3, 2025
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Stereotactic Radiosurgery for Gynecologic Cancer
Published on: April 17, 2012
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Stereotactic Radiosurgery for Glomus Jugulare Tumors: Systematic Review and Meta-Analysis
Vera Ong1, Alexandre J Bourcier1, Timothy J Florence1
1Department of Neurosurgery, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA.
World Neurosurgery
|February 21, 2022
Summary
Stereotactic radiosurgery (SRS) offers a 95% tumor control rate for glomus jugulare tumors (GJTs). This noninvasive treatment also achieved a 47% improvement in patient symptoms, suggesting its suitability for these skull base tumors.
Area of Science:
- Neurosurgery
- Oncology
- Radiology
Background:
- Glomus jugulare tumors (GJTs) are benign paragangliomas located at the jugular foramen.
- Surgical resection is traditional, but proximity to neurovasculature poses risks.
- Stereotactic radiosurgery (SRS) presents a noninvasive alternative for GJT management.
Purpose of the Study:
- To evaluate the efficacy of stereotactic radiosurgery (SRS) as a treatment option for glomus jugulare tumors (GJTs).
Main Methods:
- A meta-analysis was conducted by searching PubMed, Web of Science, Scopus, and Cochrane databases.
- Studies published up to March 2019 focusing on radiosurgery for GJTs were included.
- The screening process adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
Main Results:
- The analysis included 23 studies with 460 patients.
- The aggregate tumor control rate was 95% (95% CI, 93%-97%).
- A 47% overall clinical status improvement rate was observed (95% CI, 37%-57%).
Conclusions:
- SRS demonstrates a high tumor control rate (95%) and significant symptomatic improvement (47%) for glomus jugulare tumors.
- These findings suggest SRS is a viable noninvasive treatment for these hypervascular skull base tumors.
- Further research is recommended to solidify the role of SRS in GJT management.
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