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Recent Stem Cell Research on Hemorrhagic Stroke : An Update.

Jong-Tae Kim1, Dong Hyuk Youn1, Bong Jun Kim1

  • 1Institute of New Frontier Research, Hallym University College of Medicine, Chuncheon, Korea.

Journal of Korean Neurosurgical Society
|February 23, 2022
PubMed
Summary

Stem cell research for hemorrhagic stroke is underdeveloped, especially in Korea, despite its potential in regenerative medicine. This review covers preclinical and clinical studies, and discusses domestic research and future directions.

Keywords:
Hemorrhage strokeStem cellTherapeutics

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • Stem cell research for stroke is advancing, but hemorrhagic stroke remains understudied compared to ischemic stroke.
  • Current hemorrhagic stroke stem cell research is concentrated in the USA and China, with limited activity in Korea.
  • Many Korean neurosurgeons are unfamiliar with stem cell research and treatments, despite growing interest in regenerative medicine and increased life expectancy.

Purpose of the Study:

  • To summarize preclinical rodent studies and clinical trials of stem cells for hemorrhagic stroke.
  • To discuss the current state of domestic stem cell research for hemorrhagic stroke in Korea.
  • To provide future perspectives on stem cell research for hemorrhagic stroke.

Main Methods:

  • Systematic review of preclinical rodent studies on stem cells for hemorrhagic stroke.
  • Analysis of reported clinical trials involving stem cells for hemorrhagic stroke.
  • Review of domestic investigations and literature on stem cell research in Korea.

Main Results:

  • Limited preclinical and clinical research specifically targeting hemorrhagic stroke globally.
  • Significant research gap in Korea concerning stem cell applications for hemorrhagic stroke.
  • Growing interest in regenerative medicine necessitates further investigation into stem cell therapies.

Conclusions:

  • Stem cell therapy holds promise for hemorrhagic stroke, but requires more dedicated research, particularly in Korea.
  • Increased awareness and training are needed for neurosurgeons regarding stem cell treatments.
  • Future research should focus on bridging the gap in domestic studies and exploring therapeutic potential.