Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Ralf Bartenschlager1,2

  • 1Zentrum für Infektiologie Molekulare Virologie, Universität Heidelberg, Im Neuenheimer Feld 344, D-69120 Heidelberg, Deutschland.

Biospektrum : Zeitschrift Der Gesellschaft Fur Biologishe Chemie (GBCH) Und Der Vereinigung Fur Allgemeine Und Angewandte Mikrobiologie (VAAM)
|February 23, 2022
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The hepatitis E virus capsid protein forms amyloid-like fibrils that sequester TANK-binding kinase 1 to dampen antiviral responses.

Cell reports·2026
Same author

Renewed momentum for HCV and HCC research.

Journal of hepatology·2026
Same author

ProTides for Antiviral Activity Beyond Liver Cells.

Chemistry (Weinheim an der Bergstrasse, Germany)·2026
Same author

Correction: RBM39 shapes innate immunity by controlling expression of key factors of the interferon response.

Frontiers in immunology·2026
Same author

CDK8 and CDK19 Mediator kinases are required for hepatitis delta virus replication.

Hepatology (Baltimore, Md.)·2026
Same author

Reconstitution of interferon regulatory factor 7 expression restores interferon beta induction in Huh7 cells.

Journal of virology·2025
Same journal

Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)·2023
Same journal

Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)·2023
Same journal

Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)·2023
Same journal

Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)·2023
Same journal

Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)·2023
Same journal

Biospektrum : Zeitschrift der Gesellschaft fur Biologishe Chemie (GBCH) und der Vereinigung fur Allgemeine und Angewandte Mikrobiologie (VAAM)·2023
See all related articles

The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, replicates in the cytoplasm. Understanding its replication cycle is crucial for developing effective countermeasures against this RNA virus.

Area of Science:

  • Virology
  • Molecular Biology
  • Immunology

Context:

  • The ongoing COVID-19 pandemic, caused by SARS-CoV-2, has profound global societal and economic impacts.
  • SARS-CoV-2 is a positive-strand RNA virus that induces cell death and a significant inflammatory immune response.
  • Viral replication occurs within specialized cytoplasmic structures known as replication organelles.

Purpose:

  • To provide a concise overview of the SARS-CoV-2 replication cycle.
  • To highlight key mechanisms of viral RNA synthesis and cellular interaction.

Summary:

  • SARS-CoV-2 replication takes place in the cytoplasm, shielded within replication organelles.
  • These organelles facilitate the synthesis of viral RNA, protecting it from host defenses.
  • The virus's life cycle involves intricate steps of replication and assembly.

Related Experiment Videos

Impact:

  • Understanding the SARS-CoV-2 replication cycle is fundamental for developing antiviral therapies.
  • Insights into viral replication can inform strategies to mitigate the pandemic's impact.
  • This knowledge aids in comprehending the pathogenesis of SARS-CoV-2 infection.