Related Experiment Video
Updated: Oct 2, 2025
08:06
Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
9.1K
The Effects of Modified Intermittent Fasting in Psoriasis (MANGO): Protocol for a Two-Arm Pilot Randomized Controlled
Lynda Grine1,2, Niels Hilhorst1,2, Nathalie Michels3
1Dermatology Research Unit, Department of Head and Skin, Ghent University, Ghent, Belgium.
JMIR Research Protocols
|February 23, 2022
Summary
This study investigates modified intermittent fasting (MIF) for psoriasis patients, assessing its impact on skin, gut, and metabolic health. Results will explore MIF
Area of Science:
- Dermatology
- Gastroenterology
- Metabolic Health
- Nutritional Science
Background:
- Psoriasis is a complex condition linked to metabolic syndrome and leaky gut.
- Dietary interventions show potential for managing psoriasis severity.
- The impact of diet on psoriasis comorbidities remains unclear.
Purpose of the Study:
- To investigate the effects of modified intermittent fasting (MIF) on skin, gut, and metabolic health in psoriasis patients.
- To assess changes in psoriasis severity, gut permeability, and inflammation markers.
- To explore MIF as a potential non-pharmacological treatment for psoriasis.
Main Methods:
- A 2-arm pilot randomized controlled open cross-over study involving 24 psoriasis patients.
- Participants completed 12 weeks of MIF followed by 12 weeks of a regular diet, or vice versa.
- Assessment included disease severity, quality of life, gut/skin integrity, and inflammatory/metabolic markers.
Main Results:
- 24 participants were enrolled in the study.
- The final study visit was scheduled for June 2021.
Conclusions:
- The study aims to elucidate MIF's effects on psoriasis severity and gut health.
- It will map marker evolution (permeability, inflammation) in response to MIF versus a regular diet.
- Findings may improve understanding of psoriasis development and non-pharmacological treatment options.
