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Updated: Oct 2, 2025

Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma
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Therapy Testing in a Spheroid-based 3D Cell Culture Model for Head and Neck Squamous Cell Carcinoma

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Current Trends in Precision Medicine and Next-Generation Sequencing in Head and Neck Cancer

Roberto N Solis1, Dustin A Silverman1, Andrew C Birkeland2

  • 1Department of Otolaryngology-Head and Neck Surgery, University of California, Davis, 2521 Stockton Blvd., Suite 7200, Sacramento, CA, 95817, USA.

Current Treatment Options in Oncology
|February 23, 2022
PubMed
Abstract

Insights

Precision medicine and next-generation sequencing (NGS) offer future promise for head and neck squamous cell carcinoma (HNSCC) treatment, moving beyond traditional therapies. Challenges like tumor heterogeneity must be addressed for effective integration of these advanced approaches.

Area of Science:

  • Oncology
  • Genomics
  • Precision Medicine

Background:

  • The current standard of care for head and neck squamous cell carcinoma (HNSCC) relies on surgery, radiation, and chemotherapy.
  • While immune checkpoint inhibitors and targeted therapies show promise, a single 'magic bullet' approach is unlikely for HNSCC.
  • Advances in precision medicine and next-generation sequencing (NGS) are emerging as potential future treatment modalities.

Purpose of the Study:

  • To review the current status of precision medicine and NGS in HNSCC.
  • To explore future opportunities for integrating these advanced technologies into HNSCC treatment.
  • To highlight challenges and the need for evidence-based guidelines for NGS implementation.

Main Methods:

  • This is a review article, synthesizing current literature and expert opinion.
  • Discussion focuses on the potential roles of precision medicine and NGS in HNSCC.
  • Identifies challenges such as tumor heterogeneity and the need for clinical validation.

Main Results:

  • Precision medicine and NGS can enable better patient stratification using predictive biomarkers and targetable mutations.
  • These technologies may lead to novel combinatorial treatment regimens for HNSCC.
  • Significant challenges remain, including inter- and intratumor heterogeneity and the need for further clinical trials.

Conclusions:

  • Precision medicine and NGS hold significant future potential for improving HNSCC outcomes.
  • Overcoming challenges and establishing evidence-based guidelines are crucial for clinical adoption.
  • Continued research and validation are necessary to fully realize the benefits of NGS in HNSCC care.
Keywords:
Next-generation sequencingPersonalized medicinePrecision medicine head and neck cancerTargeted therapies

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