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Updated: Oct 2, 2025
Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis
Published on: April 17, 2017
Lipid profile changes in patients with COVID-19 referred to medical centers in Kermanshah, Iran; a case-control study
Shahab Changaripour1, Hosna Sarvazad1, Maryam Barghi2
1Clinical Research Development Center, Imam Reza Hospital, 48464Kermanshah University of Medical Sciences, Kermanshah University of Medical Sciences, Kermanshah, Iran.
Insights
Blood lipid profiles, including cholesterol, differ between severe and less severe cases of coronavirus disease 2019 (COVID-19). Low-density lipoprotein cholesterol (LDL-C) may indicate COVID-19 severity.
Area of Science:
- Biochemistry
- Infectious Diseases
- Clinical Medicine
Background:
- Coronavirus disease 2019 (COVID-19) is a global health crisis.
- Understanding metabolic changes associated with COVID-19 severity is crucial for patient management.
Purpose of the Study:
- To evaluate blood lipid profiles in patients with COVID-19.
- To explore the association between lipid profiles and COVID-19 disease severity.
Main Methods:
- A case-control study was conducted with 132 participants, including COVID-19 patients (severe/ICU and less severe/outpatient) and healthy controls.
- Lipid profiles (cholesterol, HDL-C, LDL-C) were measured and compared across groups.
- Associations between lipid levels and disease severity were analyzed.
Main Results:
- Patients with COVID-19 had lower mean cholesterol levels compared to controls.
- High-density lipoprotein cholesterol (HDL-C) was higher in severe (ICU) cases versus outpatients.
- Low-density lipoprotein cholesterol (LDL-C) was lower in severe (ICU) cases versus outpatients and associated with disease severity.
Conclusions:
- Significant differences exist in lipid profiles between severe and less severe forms of COVID-19.
- Low-density lipoprotein cholesterol (LDL-C) may serve as a potential biomarker for predicting COVID-19 severity.
Objective:
To evaluate blood lipid profiles in patients with coronavirus disease 2019 (COVID-19), and to explore the association with disease severity.
Methods:
This case-control study included patients with COVID-19, referred to two medical centers in Kermanshah, Iran (between July 2020 and December 2020), and healthy controls. Lipid profiles were evaluated in patients who were grouped according to severe (intensive care unit [ICU]), or less severe (outpatient), forms of COVID-19, and in healthy controls, and were compared among the three groups.
Results:
A total of 132 participants were included, comprising ICU (n = 49), outpatient (n = 48) and control (n = 35) groups. Mean cholesterol levels were lower in the patient groups than in controls; high-density lipoprotein cholesterol (HDL-C) levels were higher in the ICU group versus outpatients, and low-density lipoprotein cholesterol (LDL-C) levels were lower in the ICU group versus outpatients. The frequency of diabetes and hypertension was higher in the ICU group than in the outpatient group. Furthermore, LDL-C level was associated with disease severity (odds ratio 0.966, 95% confidence interval 0.944, 0.989).
Conclusion:
Lipid profiles differ between severe and less severe forms of COVID-19. LDL-C level may be a useful indicator of COVID-19 severity.
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