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Valproate Induced Acute Pancreatitis - A Unique Case Report.
Vikramaditya Chauhan1, Munish Sharma1, Ajita Kapur2
1Department of General Surgery, Kalpana Chawla Government Medical College, Karnal, India.
Current Drug Safety
|February 24, 2022
Summary
Valproate, a common seizure medication, can cause acute pancreatitis in children. Prompt recognition and discontinuation of valproate are crucial for resolving this serious complication.
Area of Science:
- Pediatric Gastroenterology
- Clinical Pharmacology
Background:
- Valproate is a first-line antiepileptic drug for pediatric seizure disorders.
- Drug-induced pancreatitis is a known, albeit uncommon, adverse effect of valproate therapy.
- Early recognition is vital to prevent severe outcomes.
Observation:
- A 13-year-old presented with severe abdominal pain, distension, vomiting, and constipation.
- Initial diagnosis was pyoperitoneum/peritonitis based on clinical signs and ultrasound.
- Intraoperative findings during exploratory laparotomy revealed acute pancreatitis.
Findings:
- The patient had a six-month history of valproate use for generalized tonic-clonic seizures.
- Discontinuation of valproate led to complete resolution of pancreatitis symptoms.
- This case highlights valproate-induced acute pancreatitis mimicking a surgical abdomen.
Implications:
- Clinicians must consider valproate-induced pancreatitis in pediatric patients with abdominal symptoms.
- Caregivers should be educated about this potential adverse effect of valproate.
- Timely diagnosis and management are essential to avoid morbidity and mortality.
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