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Published on: April 26, 2012
Metronidazole Induced Cerebellar Toxicity: A Case Report
Shova Sapkota1, Aliska Niroula1, Rina Prajapati2
1Kathmandu Medical College and Teaching Hospital, Sinamangal, Kathmandu, Nepal.
Abstract:
Metronidazole is a widely used antibiotic against bacterial and protozoan infections. Even though the therapeutic use of the drug is high, it is associated with some severe side effects like neurotoxicity such as optic neuropathy, peripheral neuropathy, encephalopathy and cerebellar toxicity. We present a case of a 55-years male presented with dysarthria, who had positive cerebellar sign and magnetic resonance imaging findings suggestive of metronidazole induced cerebellar toxicity following metronidazole therapy for two months in a case of liver abscess. And, the symptoms resolved after cessation of metronidazole.
Insights
Metronidazole can cause severe neurotoxicity, including cerebellar issues. This case highlights reversible cerebellar toxicity from this common antibiotic, emphasizing the need for awareness.
Area of Science:
- Neurology
- Pharmacology
- Infectious Diseases
Background:
- Metronidazole is a crucial antibiotic for bacterial and protozoan infections.
- High therapeutic use is linked to severe neurotoxic side effects.
- Reported neurotoxicity includes optic neuropathy, peripheral neuropathy, encephalopathy, and cerebellar toxicity.
Observation:
- A 55-year-old male presented with dysarthria and positive cerebellar signs.
- Clinical presentation was suggestive of metronidazole-induced cerebellar toxicity.
- The patient had undergone two months of metronidazole therapy for a liver abscess.
Findings:
- Magnetic resonance imaging (MRI) confirmed findings consistent with cerebellar toxicity.
- Cerebellar signs and symptoms were directly attributed to metronidazole use.
- Cessation of metronidazole led to the complete resolution of symptoms.
Implications:
- This case underscores the potential for metronidazole-induced cerebellar toxicity.
- Highlights the importance of recognizing and managing neurotoxic side effects of metronidazole.
- Suggests prompt drug withdrawal can lead to symptom recovery in metronidazole-induced neurotoxicity.
