Mesothelioma with Nonbacterial Thrombotic Endocarditis: A Case Report

Area of Science:

• Cardiology
• Oncology
• Pathology

Background:

• Non-bacterial thrombotic endocarditis (NBTE) is a rare condition involving noninfectious vegetations on heart valves.
• NBTE is frequently associated with underlying malignancies, autoimmune disorders, and disseminated intravascular coagulation.
• Embolic manifestations are more common presenting features than cardiac failure in NBTE.

Observation:

• This report details a case of NBTE in a 35-year-old male inpatient.
• The patient was diagnosed with pleural mesothelioma, a rare malignancy of the pleura.
• This represents a rare association between NBTE and pleural mesothelioma.

Findings:

• The case underscores the importance of clinical suspicion for NBTE in cancer patients presenting with embolic phenomena.
• NBTE can occur with various malignancies, including rare ones like pleural mesothelioma.
• Diagnostic vigilance is crucial for identifying NBTE, especially when co-occurring with neoplastic diseases.

Implications:

• Increased awareness of NBTE in patients with malignancy, particularly rare cancers, is warranted.
• Early diagnosis and management of NBTE can potentially improve patient outcomes.
• Further research into the mechanisms linking NBTE and specific malignancies may reveal new therapeutic targets.